Doctor Three-Brains is a villain on the series WordGirl, voiced by Brian Posehn. He first appeared in the episode "Crime Takes a Holiday", when Doctor Two-Brains seeks a replacement villain to take over for him when he goes on a vacation cruise he won from Dairy Villains Monthly. Glen then shows up at the auditions and claims to be Two-Brains' number one fan. He then proceeds to claim he could improve Two-Brains' crimes, much to the villain's annoyance. Because Two-Brains did not feel that Glen was a competent replacement for him, due to his conceitedness and foolish ideas, he rejected Glen's audition.